i-Bio PhD proposal: Studying extracellular matrix assembly in a multi-species model biofilm using Raman microspectroscopy

Envoyé par haguiar 
The extracellular matrix is the polymer soft architecture of a bacterial biofilm. It physically stabilizes the cells and their offspring, giving rise to a 3D living material expressing emergent properties. How this organ assembles in the context of a multispecies biofilm is completely unknown. To gain insights into this question we aim at implementing a recent innovation of Raman microspectroscopy — the compressive Raman framework1 — on a 4-species model biofilm growing under flow of nutrients in a millifluidic channel2. (More details in [bit.ly])

The project will be co-supervised by Nelly Henry* - Laboratoire Jean Perrin (IBPS, CNRS, SU) and Hilton B. de Aguiar** – Laboratoire Kastler Brossel (ENS, CNRS, SU). Paris, France.

Candidate profile: Main background in physics or physico-chemistry with a strong interest in biology. A master 2 student at the interface of these disciplines would be highly appreciated. Yet a strong motivation for biological systems will also be favorably considered for a candidate with no background in biology.
Motivation, CV, Academic records and References to nelly.henry@sorbonneuniversite.fr and h.aguiar@phys.ens.fr up to June, 1st, 2020. The selected candidate will be asked to apply to i-Bio program before June 12, 2020 for an interview end of June ( [ibio.sorbonne-universite.fr] ).

[1] S. H. Donaldson Jr., H. B. de Aguiar ; J. Phys. Chem. Lett. 9 1528 (2018);
B. Sturm, F. et al. ACS Photonics 6, 1409–1415 (2019);
F. Soldevila et al. Optica 6, 341–346 (2019).

[2] P. Thomen et al. Soft Matter 16, 494-504 (2020);
Monmeyran et al., Sci Rep 8, 10336 (2018);
P. Thomen et al. PLoS ONE 12, e0175197 (2017);
N. Henry Impact, 7, 58-60 (2017);
O. Galy et al. Biophys. J. 5, 1400-1408 (2012).