Fully funded PhD [ERC] Exploring Proteins Structure with THz Nanospectroscpy

Fully funded PhD [ERC] Exploring Proteins Structure with THz Nanospectroscpy
vendredi 24 mars 2023 16:13:28
Fully funded PhD by an ERC consolidator grant

Context and objectives:
The TeraHertz range, located between optics and electronics, is currently a hotbed of research due to its potential for non-invasive probing of matter. The Institute of Electronics, Microelectronics, and Nanotechnologies (IEMN) is conducting research in the TeraHertz range using state-of-the-art TeraHertz-time-domain spectrometry (THz-TDS) to analyze solid samples (semiconductors, insulators), liquids (aqueous solutions, solvents), and gases. The team aims to develop new tools and methodology to enable THz wave investigation of the structures and functions of biological molecules such as proteins and DNA.
The study of biological molecules such as proteins and DNA is crucial for understanding the mechanisms of life and developing new drugs. TeraHertz spectroscopy is a promising tool for analyzing these molecules. However, the small size of most biological samples limits the use of conventional techniques for their analysis. Our group is developing novel THz devices based on a metallic hollow waveguide to overcome this limitation that has already shown promising results. With a prestigious ERC Consolidator Grant, we are taking this research to the next level by developing new techniques for analyzing macromolecules like proteins in the THz range. TUSCaNy project aim at exploring the hidden world of biological molecules with dedicated TeraHertz technology.

Your main mission will be to design and optimize the performance of the state-of-the-art device using advanced numerical methods, such as FDTD. You will then utilize our cutting-edge micro and nano fabrication facilities to fabricate the device using the latest generation equipment. Once fabricated, you will validate the electromagnetic performances of the device in terms of field localization and coupling. Finally, you will operate the device in broadband THz spectroscopy with various macromolecular samples under different conditions, ranging from cryogenic temperatures in a specialized cryostat to microfluidic environments. Your ultimate goal will be to obtain high-quality data that can be used to better understand the structures and functions of biological molecules.

Our team of experienced researchers at IEMN Laboratory in Lille, France, offers a vibrant environment for conducting cutting-edge research in the TeraHertz range. As part of our THz-Photonics group, you will have access to our state-of-the-art nano fabrication facilities in our 1500m2 clean room, as well as fully equipped experimental facilities. With our long-standing expertise in THz optoelectronic device conception and realization, you will work alongside our team to design and conduct innovative THz biophotonics experiments.
We are seeking a physics or engineering master graduate, or equivalent, with expertise in experimental optics, spectroscopy, electromagnetism, or Python coding. The exact tasks will be tailored to your capacities and interests, and we encourage you to contact us today to learn more about this exciting opportunity!

Key words: TeraHertz, spectroscopy, antenna, wave propagation, Microfluidics

Contact: Dr Romain Peretti : romain.peretti@cnrs.fr , please contact me for any details before a more formal application.