The application of AI to biology is leading to revolutionary achievements with Alphafold for protein folding and generative models of artificial enzymes. However, a question remains open at a higher level of organization in cells, crucial for diagnosis and therapeutic strategies: how to predict the impact of multiple gene perturbations on biological functions? The aim of the project is to developpar pnghe - Thèses hors de l'EDPIF
A mathematical and statistical approach to the origin of life: emergence of polymerization, autocatalysis and Darwinian evolution Is Darwinian evolution a surprising phenomenon? Life as we know it is governed by Darwinian evolution, but there is so far no convincing demonstration that a natural or artificial physical-chemical system is capable of autonomous Darwinian evolution outside ofpar pnghe - Thèses hors de l'EDPIF